ea0031p295 | Pituitary | SFEBES2013
Chambers Thomas
, Dean Afshan
, Driesche Sander van den
, Mitchell Rod
, MacPherson Sheila
, Anderson Richard
, Drake Mandy
, Sharpe Richard
Background: 5-Cytosine methylation of DNA is a means of encoding epigenetic information. In the testis, the generation of de novo methylation is conducted by the enzymes DNMT3a and 3b and the co-enzyme DNMT3L. Epigenetic marks made to the DNA of germ cells are important as a potential means of trans-generational carriage of environmental information. In fetal life, germ cell demethylation and remethylation are important physiological events and these overlap with key ...